DMPK Services and Capabilities

AMRI provides high-quality DMPK assays with capabilities that range from characterization of compound physicochemical properties through drug-drug interactions, bioanalytical/pharmacokinetic studies, and metabolite ID and synthesis. We conduct in vitro ADMET assays to evaluate and improve metabolism, bioavailability, pharmacology and toxicology of compounds.

  • Global facilities and An Integrated Approach Maximizes Value Through a Blended Cost Structure, Smoother Logics and A Single Point of Contact
  • Quick Turnaround Time
  • Direct Access To Technical Experts
  • Rapid Ordering System For Standard Off-The-Shelf Services
  • Competitive Pricing
  • Customizable Assay Development

AMRI’s ADMET service platform seamlessly integrates with our other discovery services to provide efficent and effective progression through the pipeline. The testing funnel below illustrates how our ADMET service platform seamlessly integrates with our other discovery services to provide efficent and effective progression through the pipeline.

Services spanning drug discovery
through pre-clinical development:
In Vitro DMPK & Bioanalytical /PK

Hit-To-Lead
  • Solubility
  • Metabolic stability
  • PAMPA permeability
  • CYP inhibition-florescene
  • Cell-based permeability
  • Plasma protein binding
  • Chemical stability
Lead Optimization
  • Metabolic clearance
  • Metabolite profiling
  • Metabolite ID
  • CYP inhibition-LCMS
  • Bioanalytical / PKs
  • Dose formulation development
  • Brain protein binding
  • Blood-plasma partitioning
Candidate Selection
  • Hepatocyte clearance
  • Reactive metabolites
  • Time-dependent CYP inhibition
  • CYP phenotype screen
  • hERG inhibition
  • Mini-Ames
  • Cytotoxity
Pre-Clinical
  • CYP inhibition
  • CYP induction
  • CYP phenotyping
  • Metabolite ID-species comparison
Amri Global

About

AMRI provides the Life Sciences community with leading global, end-to-end contract research and manufacturing services. Locations on three continents provide targeted solutions to support the discovery, development and manufacturing of therapeutics.

Specializing in:

AMRI’s Capabilities

AMRI now delivers a broader suite of capabilities across the drug discovery, development
and manufacturing spectrum. Our key business segments include:

Amri Global

Discovery and DevelopmentServices (DDS)

We provide comprehensive services from hit identification to IND, including expertise with diverse chemistry, library design and sesis, in vitro biology and pharmacology, drug metabolism and pharmacokinetics, as well as natural products.

Amri Global

Active Pharmaceutical
Ingredients (API)

AMRI supports the chemical development and cGMP manufacture of complex APIs, including potent and cytotoxic compounds, controlled substances, steroids, hormones and sterile APIs.

Amri Global

Drug Product
Manufacturing (DPM)

We support development through commercial-scale production of complex liquid-filled and lyophilized parenterals, sterile suspensions and ophthalmic formulations.

Accelerate your Drug Discovery Pipeline. Request a Quote

Why choose AMRI?

  • Premier provider of global discovery, development and manufacturing services for pharmaceutical industry
  • World-class, Integrated Drug Discovery Centers with leading-edge technology platforms and scientific facilities
  • Innovative services across the entire drug pathway continuum via strategic partnerships and acquisitions
  • Seamless project transition - from early discovery through commercial supply, providing competitive advantage for customers
Request a Quote